Hydroxypropyl methylcellulose (HPMC) ke selulose se se nang ionic, se qhibilihang ka metsing se kopantsoeng le ether.Ponahalo e tšoeu ho isa ho phofshoana e mosehla hanyenyane kapa lintho tse granular, tse sa latsoeheng, tse sa nkhang hamonate, ha li na chefo, li tsitsitse ka lik'hemik'hale, 'me li qhibiliha ka metsing ho etsa tharollo e boreleli, e bonaletsang le ea viscous.E 'ngoe ea thepa ea bohlokoa ka ho fetisisa ea hydroxypropyl methylcellulose ha e sebelisoa ke hore e eketsa viscosity ea mokelikeli.Phello e teteaneng e itšetlehile ka tekanyo ea polymerization (DP) ea sehlahisoa, bongata ba cellulose ether ka tharollo ea metsi, sekhahla sa ho kuta, le mocheso oa tharollo.Le lintlha tse ling.
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Mofuta oa mokelikeli oa tharollo ea metsi ea HPMC
Ka kakaretso, khatello ea maikutlo ea mokelikeli ka ho phalla ha shear e ka hlalosoa e le ts'ebetso ea sekhahla sa ho kuta feela ƒ(γ), hafeela e sa itšetlehe ka nako.Ho latela sebopeho sa ƒ(γ), maro a ka aroloa ka mefuta e fapaneng, e leng: maro a Newtonian, maro a dilatant, maro a pseudoplastic le maro a polasetiki a Bingham.
Li-cellulose ethers li arotsoe ka mekhahlelo e 'meli: e' ngoe ke non-ionic cellulose ether 'me e' ngoe ke ionic cellulose ether.Bakeng sa rheology ea mefuta ena e 'meli ea cellulose ethers.SC Naik et al.e entse boithuto bo bapisang bo phethahetseng le bo hlophisehileng ka hydroxyethyl cellulose le sodium carboxymethyl cellulose tharollo.Liphetho li bontšitse hore litharollo tsa ether tse seng tsa ionic cellulose le litharollo tsa ionic cellulose ether e ne e le pseudoplastic.Phallo, ke hore, phallo e seng ea Newtonian, e atamela mekelikeli ea Newtonian feela maemong a tlase haholo.Pseudoplasticity ea tharollo ea hydroxypropyl methylcellulose e phetha karolo ea bohlokoa ts'ebetsong.Ka mohlala, ha e sebelisoa ka liphahlo, ka lebaka la litšobotsi tse fokolang tsa ho kuta tsa tharollo ea metsi, viscosity ea tharollo e fokotseha ka ho eketseha ha sekhahla sa ho kuta, e leng se loketseng ho hasana ha likaroloana tsa pigment, hape ho eketsa metsi a ho roala. .Phello e kholo haholo;ha u ntse u phomotse, viscosity ea tharollo e batla e le khōlō, e thibelang ka katleho ho behoa ha likaroloana tsa pigment ka ho roala.
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Mokhoa oa Teko oa HPMC Viscosity
Pontšo ea bohlokoa ea ho lekanya phello e teteaneng ea hydroxypropyl methylcellulose ke ponahalo e hlakileng ea tharollo ea metsi.Mekhoa ea ho lekanya ea viscosity e bonahalang hangata e kenyelletsa mokhoa oa capillary viscosity, mokhoa oa rotational viscosity le mokhoa oa ho putlama ha bolo.
moo: ke viscosity e bonahalang, mPa s;K ke viscometer kamehla;d ke boima ba sampuli ea tharollo ho 20/20 ° C;t ke nako ea hore tharollo e fete karolong e ka holimo ea viscometer ho ea ho letšoao le ka tlaase, s;Nako eo oli e tloaelehileng e phallang ka viscometer e lekantsoe.
Leha ho le joalo, mokhoa oa ho lekanya ka capillary viscometer o thata haholo.Li-viscosities tsa li-cellulose ethers tse ngata ho thata ho li hlahloba ka ho sebelisa capillary viscometer hobane litharollo tsena li na le likaroloana tsa lintho tse sa tsitsang tse fumanoang feela ha capillary viscometer e koetsoe.Ka hona, bahlahisi ba bangata ba sebelisa li-viscometers tse potolohang ho laola boleng ba hydroxypropyl methylcellulose.Li-viscometer tsa Brookfield li sebelisoa hangata linaheng tse ling, 'me li-viscometer tsa NDJ li sebelisoa Chaena.
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Lintho tse susumetsang tsa HPMC viscosity
3.1 Kamano le tekanyo ea ho kopanya
Ha likarolo tse ling li lula li sa fetohe, viscosity ea tharollo ea hydroxypropyl methylcellulose e lekana le tekanyo ea polymerization (DP) kapa boima ba molek'hule kapa bolelele ba ketane ea molek'hule, 'me e eketseha ka keketseho ea tekanyo ea polymerization.Phello ena e bonahala haholo tabeng ea tekanyo e tlaase ea polymerization ho feta tabeng ea boemo bo phahameng ba polymerization.
3.2 Kamano pakeng tsa viscosity le mahloriso
Viscosity ea hydroxypropyl methylcellulose e eketseha ka keketseho ea bongata ba sehlahisoa ka har'a tharollo e nang le metsi.Esita le phetoho e nyenyane ea mahloriso e tla baka phetoho e kholo ea viscosity.Ka lebitso la viscosity ea hydroxypropyl methylcellulose Phello ea phetoho ea mahloriso a tharollo holim'a viscosity ea tharollo e hlakile haholoanyane.
3.3 Kamano lipakeng tsa viscosity le sekhahla sa ho kuta
Hydroxypropyl methylcellulose aqueous solution e na le thepa ea ho kuta moriri.Hydroxypropyl methylcellulose ea viscosity e fapaneng ea lebitso e lokisoa ka tharollo ea metsi a 2%, 'me viscosity ea eona ka litekanyetso tse fapaneng tsa ho kuta e lekantsoe ka ho latellana.Liphetho ke tse latelang Joalokaha ho bontšitsoe setšoantšong.Ka sekhahla se tlase sa ho kuta, viscosity ea tharollo ea hydroxypropyl methylcellulose ha ea ka ea fetoha haholo.Ka keketseho ea sekhahla sa ho kuta, viscosity ea hydroxypropyl methylcellulose tharollo e nang le viscosity e phahameng ea lebitso e fokotsehile ka ho hlaka, ha tharollo e nang le viscosity e tlase e sa fokotsehe ka ho hlaka.
3.4 Kamano pakeng tsa viscosity le mocheso
The viscosity ea tharollo ea hydroxypropyl methylcellulose e ameha haholo ke mocheso.Ha mocheso o ntse o eketseha, viscosity ea tharollo ea fokotseha.Joalokaha ho bontšitsoe setšoantšong, e lokiselitsoe ho ba tharollo ea metsi e nang le motsoako oa 2%, 'me phetoho ea viscosity ka ho eketseha ha mocheso e lekantsoe.
3.5 Lintlha tse ling tse susumetsang
The viscosity ea tharollo ea metsi ea hydroxypropyl methylcellulose e boetse e angoa ke li-additives ka tharollo, boleng ba pH ba tharollo, le ho senyeha ha likokoana-hloko.Hangata, e le ho fumana ts'ebetso e ntle ea viscosity kapa ho fokotsa litšenyehelo tsa tšebeliso, hoa hlokahala ho eketsa liphetoho tsa rheology, tse kang letsopa, letsopa le fetotsoeng, phofo ea polymer, starch ether le aliphatic copolymer, ho tharollo ea metsi ea hydroxypropyl methylcellulose., 'me li-electrolyte tse kang chloride, bromide, phosphate, nitrate, joalo-joalo li ka boela tsa ekeletsoa ka tharollo ea metsi.Li-additives tsena li ke ke tsa ama feela thepa ea viscosity ea tharollo ea metsi, empa hape e ama lisebelisoa tse ling tsa kopo ea hydroxypropyl methylcellulose tse kang ho boloka metsi., sag resistance, joalo-joalo.
The viscosity ea tharollo ea metsi ea hydroxypropyl methylcellulose e batla e sa amehe ke acid le alkali, 'me ka kakaretso e tsitsitse ho tloha 3 ho ea ho 11. E ka mamella palo e itseng ea li-acids tse fokolang, tse kang formic acid, acetic acid, phosphoric acid. , boric acid, citric acid, joalo-joalo Leha ho le joalo, acid e concentrated e tla fokotsa viscosity.Empa caustic soda, potassium hydroxide, metsi a lime, joalo-joalo ha e na phello e fokolang ho eona.Ha ho bapisoa le li-cellulose ethers tse ling, hydroxypropyl methylcellulose aqueous solution e na le botsitso bo botle ba likokoana-hloko, lebaka le ka sehloohong ke hore hydroxypropyl methylcellulose e na le lihlopha tsa hydrophobic tse nang le boemo bo phahameng ba ho fetola le tšitiso ea steric ea lihlopha Leha ho le joalo, kaha karabelo ea ho fetola hangata ha e tšoane, unit ea anhydroglucose e sa nkeloa sebaka ke sebaka. e senyeha habonolo ke likokoana-hloko, e leng se bakang ho senyeha ha limolek'hule tsa cellulose ether le chain scission.Tshebetso ke hore viscosity e bonahalang ea tharollo ea metsi e fokotseha.Haeba ho hlokahala ho boloka tharollo ea metsi ea hydroxypropyl methylcellulose nako e telele, ho kgothaletswa ho eketsa palo e nyenyane ea moemeli oa antifungal e le hore viscosity e se ke ea fetoha haholo.Ha u khetha li-anti-fungal agents, li-preservative kapa li-fungicides, u lokela ho ela hloko polokeho, 'me u khethe lihlahisoa tse se nang chefo ho' mele oa motho, tse nang le thepa e tsitsitseng le e sa nkheng, joalo ka li-fungicides tsa AMICAL tsa DOW Chem, li-preservatives tsa CANGUARD64, li-bacteria tsa FUELSAVER. le lihlahisoa tse ling.e ka bapala karolo e tsamaellanang.
Nako ea poso: Oct-20-2022