Litlhaloso tsa Pharmacecticas ke litšoaneleho le litlatsetso tse sebelisitsoeng tlhahisong ea meriana le litaelo, 'me ke karolo ea bohlokoa ea meriana ea meriana. Joaloka phuna ea tlhaho ea polymer e nkiloeng, Ether e Nyane e Biodegradation, Nydroxyproplayyyl Celdlolese e tsejoang. Hajoale, lihlahisoa tsa likhoele tsa lapeng e rekisoang haholo libakeng tse bohareng le tse tlase tsa indasteri, 'me boleng bo eketsehileng ha bo phahame. Indasteri e hloka phetoho ka potlako le ntlafatso ho ntlafatsa ts'ebeliso e phahameng ea lihlahisoa.
Monyetla oa 'maraka oa meriana oa meriana o moholo o moholo
Bareki ba pharmacetic ba bapala karolo ea bohlokoa ho nts'etsopele le tlhahiso ea liforomo. Ka mohlala, litokisetso tsa ho lokolla, lisebelisoa tsa polymer tse kang celluloulos li sebelisoa e le litokisetso tsa lithethefatsi tse koahetsoeng. Litokisetso le litokisetso tse bolokiloeng li sebelisitsoe haholo. Tsamaisong ena, li-polyments tse kang Ether ka kakaretso li sebelisoa e le bakuli ba lithethefatsi ho laola sekhahla sa ho lokolla butle ka nako e itseng ho fihlela sepheo se sebetsang.
Ho latela lipalo-palo tse tsoang Zheyan ho buisana le mefuta ea lipatlisiso, ho na le mefuta e ka bang 500 ea mefuta ea United States, empa ho na le lekhalo le fetang la 3,000, 'me mefuta e ntse e nyane. Ho na le bokhoni ba ntlafatso ea 'maraka o moholo. Hoa utloahala hore li-rathmacentium tse leshome tsa meriana tsa naha li na le li-glatin li-gelatin
Litlhahiso tse tšeletseng tsa meriana ea li-ramauloti tse tšeletseng
Chesi ea Che ea Che ea Chese ea Sechaba e hlahisoang ke karabelo ea alkali cellular le moemeli ea iphetetsang tlasa maemo a itseng. Ke sehlahisoa seo lihlopha tsa hydroyl ho tsona ho Mamalo a celdoulosecules kapa ho nkeloa sebaka ke lihlopha tse ling. E-'E-' e-ba-'-bo-'m'ae e sebelisoa haholo masimong a peterole, thepa ea meho, makhapetla, lijo, lijo le lik'hemik'hale, lijo le letsatsi le letsatsi. Masimong a fapaneng, lihlahisoa tsa lihlopha tsa lihlapi tsa Pharmacticaly ke tsona masimong a phahameng a indasteri, ka boleng bo phahameng. Ka lebaka la litlhokahalo tsa boleng ba boleng, tlhahiso ea meriana ea li-rariloulous-ether e ngata le eona e thata. Ho ka boleloa hore boleng ba lihlahisoa tsa sehlopha li ka emela matla a botekgeniki a likhohlo tsa cellulose. Hangata cellulolose Ether o eketsoa e le blocker, thepa ea matrix le thickener ho etsa lisebelisoa tse matla tsa matrix, limolema tsa filimi e tšehelitsoeng - enc.
Sodium cisboxeMethyl cellulolose
CARBOExxEMethyl Cedium Sodium (CMC-NA) ke Cellulose Ether Ether Will Cellulose le tlhahiso e kholo le ea kantle ho naha. Ke selefounu ea ioni ea ionic Cmc-na e sebelisoa haholo ke meriana e tloaelehileng ea meriana. Hangata ho sebelisoa e le tšebeliso ea litokisetso tse tiileng, viocosion-le ho emisoa le ho emisoa le ho emisoa le lisebelisoa tse qhibilihang ka metsi le lisebelisoa tsa lifilimi. Hangata e sebelisoa e le thepa ea lithethefatsi ea lithethefatsi tsa lithethefatsi tse kholisitsoeng ea lifilimi le tokiso ea matrix ea khokelo ea matla e tsitsitseng (e laoloang) litokisetso.
Ntle le sodium carboxemesylcell Seketsoana sa Croscarmese Sodium Ha moemeli ea qabolang, motlalehi oa Glyne, Propyic Atyshdride onhydride le Alipic Ahhydride le Adric Ahhdriz Ahhydride e ka sebelisoa. Sodium ea Croscarmelose e sebelisoa e le moferefere oa matlapa, li-capsules le granules litokisetsong tsa molomo. E itšetleha ka capillary le litlamorao tse ruruhang ho qhalana. E na le matla a ho feto-fetoha le matla le matla a ho teba. Boithuto bo bonts'ang hore tekanyo e tšehang ea Croscarmelose sodi
Methylcelldoulose
Methyl cellulosese (MC) ke selefounu e seng ea Ionic e le 'ngoe e entsoeng ho tsoa ho k'hothone le lehong ka alkalide etheride chlolide. Methylcellll E sebelisoa hohle ho bakhethoa ba meriana, 'me e sebelisoa matlapeng a marang-rang, litokisetso tsa apphlharm, li-capsuls tsa molomo, matlapa a molomo le litokisetso tsa holimo. Ntle le moo, litokisetso tsa tokiso ea hydrophilic li ntse li fana ka lisebelisoa tsa katrix tsa pente, lisebelisoa tsa filimi e tšehelitsoeng ke li-microcaple tse tšehelitsoeng - jj.
HydroxypropypropyLohlDoulose
Hydroxypropypropinyl Methylcellllulose (HPMC) ke sesebelisoa se seng sa Iona se kopaneng se entsoeng ho tsoa ho Cotton le Lehong le nang le alkalide. Ha e na lintho tse sa utloahaleng Hydroxypropypropike methylcelulose ke mefuta e mengata ea mll cellulose, litekanyetso le boleng li ntse li eketseha ka potlako China lilemong tse 15 tse fetileng. Hape ke e 'ngoe ea li-raricities tse sebelisoang haholo malapeng le kantle ho naha. lilemo tsa nalane. Hajoale, ts'ebeliso ea HPMC e bonahala haholo likarolo tse ling tse latelang:
E 'ngoe e tšoana le ho hlaba le ho senyeha. Joaloka 'mele, HPMC e ka etsa hore ho be bonolo ho koloba,' me e ka holisa linako tse makholo ka mor'a ho ntlafatsa sekhahla sa disshoe kapa sekhahla sa ho lokolla letlapa. HPMC e na le lipono tse matla, tse ka ntlafatsang pono ea sebopeho le ho ntlafatsa tumello ea lisebelisoa tse tala tse nang le crisp kapa polingo ea brittle. HPMC e nang le Viscosity e tlase e ka sebelisoa e le molumo ebile ha ho na pono, 'me ba nang le litšoantšo tse phahameng li ka sebelisoa e le ngata haholo.
Ea bobeli e le thepa e tokisitsoeng le e laoloang e hlophisehileng le e laoloang bakeng sa litokisetso tsa molomo. HPMC ke ntho e tloaelehileng ea Mydrogel Mattrix litokisetsong tse tšehelitsoeng. Sehlopha sa Vscosity se tlase (5-50Fa · li-HPMC li ka sebelisoa e le ntho e thibelang bashebelli ba li-capsufsical, tsa hydrophilic gel matrix e tšehelitsoeng ke hydrophilic. HPMC e qhibiliha mokelikeli oa gastrointestinate Ke thepa e boima haholo lits'ebetsong tsa tokiso e ileng ea emisitsoeng khafetsa e le lisebelisoa tsa tokiso tse kholisitsoeng li lokisa le litokisetso tsa lifilimi tse atlehileng.
Ea boraro e joalo ka moemeli ea etsang lifilimi tse etsang lifilimi. HPMC e na le thepa e ntle ea lifilimi. Filimi e thehileng ke eona ke junifomo, pepere, e pepeseha le ho thata, 'me ha ho bonolo ho e khomarele nakong ea tlhahiso. Haholo-holo bakeng sa lithethefatsi tse bonolo ho amohela mongobo ebile ha ho na letho, e e sebelisa haholo e le karolo ea ho itšehla thajana ebile ho thibela filimi ho fetola 'mala. HPMC e na le litlhaloso tse fapaneng tsa lipono tsa pono. Haeba e khethiloe hantle, boleng le ponahalo ea matlapa a koaetsoeng a koae li phahame ho lisebelisoa tse ling. Ho tsepamisa maikutlo a sebelisitsoeng hangata ke 2% ho 10%.
Ea bone e joalo ka thepa ea capsule. Lilemong tsa morao tjena, ka likhatiso tsa lefu-pele tsa mafu a liphoofolo tsa Lefatše tsa liphoofolo, ha a bapisoa le li-capsules tsa glatin, li indasteri e ncha ea pharma le lijo. PFIZER ea United States e atlehile ho tsoa ho HPMC ho tloha limeleng tsa tlhaho le li-capsules tsa meroho ea VCAPTM. Ha ho bapisoa le li-capsules tsa Genot Hollow, li-capsules tsa semela li na le melemo e mengata, ha ho na kotsi ea karabelo e kopanyang le botsitso. Sekhahla sa ho lokolloa ha sethethefatsi se tsitsitse, 'me liphapang tsa motho ka bo' ngoe li nyane. Kamora ho khella ha motho 'meleng oa motho, ha ho abdight mme o ka botsitso ntho e hotle ho tsoa' meleng. Mabapi le maemo a polokelo, kamora liteko tse kholo, ha ho na blottle feela tlas'a maemo a mongobo, 'me mabone a mabokose a capsules a ntse a sa amehe tlas'a maemo a tebileng a semela. Ka kutloisiso ea batho ba li-capsules tsa batho le phetoho ea likhopolo tsa bongaka malapeng le linaheng tse ling, tlhokeho ea marapo oa li-capsules e tla hola ka potlako.
Ea bohlano ke moemeli ea emisang. Tlhahiso ea ho emisoa ka metsing e emisoa ke sebopeho se sebelisoang hangata, e leng tsamaiso e sa qheletsoeng ka thata eo ho eona lithethefatsi tse sa khaotseng. Ho tsitsa ha sistimi ho khetholla boleng ba phepelo ea mosi oa ho emisoa. Tharollo ea Coloidal ea HPMC e ka fokotsa khatello e matla ea metsi, fokotsa matla a mahala a likaroloana, 'me a tsitsisa tsamaiso e sa qhaleheloang ke lerata. Ke moemeli ea sa khaotseng haholo. HPMC e sebelisoa e le thipa bakeng sa marotholi a mahlo, e nang le litaba tsa 0.45% ho 1.0%.
Contlase ea hydroxypropyl
HydroxypropypropyLe ke celluuloulose ea Ionic HPC hangata e qhibiliha ka metsing ka tlase ho 40 ° C le palo e kholo ea li-solt e amanang, 'me ts'ebetso ea eona e amana le litaba tsa sehlopha sa hydroxypropicl le tekanyo ea polymeriaption. HPC e ka lumellana le lithethefatsi tse fapaneng 'me e na le kahare ho kahare.
Hydroxypropyl cellulose (L-HPC) e sebelisoa haholo e le taolo ea letlapa le binder. -Hopc e ka ntlafatsa mathata le khanya ea letlapa, hape e ka etsa hore matlakho a iphetetsa kapele, a ntlafatsa boleng ba letlapa, le ho ntlafatsa phello e sithabetseng.
Hydroxypropyl cellulose e nkang sebaka sa hydroxypropy. H-HPC e na le thepa e ntle haholo ea lifilimi, 'me filimi e behiloeng e thata ebile e le ea bohlokoa, e ka bapisoang le lipalesa. Ts'ebetso ea filimi e ka ntlafatsoa haholoanyane ka ho ikopanya le baemeli ba bang ba mongobo, 'me hangata ho sebelisoa e le thepa ea lifilimi e tsamaeang le filimi. H-HPC e ka sebelisoa e le litaba tsa matlatoe ho lokisa matlapa a tobileng a tokiso, le liqhetsa tse peli tse tšehelitsoeng habeli.
Hydroxeeyl cellulosese
Hydroxethyl cellulosese (Hec) ke selefounu e seng ea Ionic le ether Tšimong ea bongaka, Hec e sebelisoa haholo ke le moetsi oa tšireletso, e khabisitsoeng, e thata, e leng moferefere, e thata, e leng liqhobosheane, se tiileng, sephate le liforomo tse ling. Hydroxethyl Cellulose e tlalehiloe ho The LarmaCouE / Apormation Anstern Metional and European Pharma, jj.
Sesebelisoa sa Ethyl
Sesebelisoa sa Ethyl (EC) ke e 'ngoe ea libui tse sebelisoang haholo tsa metsi. EC ha se chefo, e tsitsitseng, se tsitsitseng, tharollo ea metsi, tharollo ea asiti, acid kapa Alkali ea qhibilihileng joalo ka Ethanol le Methal. Hangata e sebelisoa solvent e sebelisoa ke Toluene / Ethanol e le 4/1 (boima) e tsoakaneng. EC e na le lits'ebeletso tse ngata litoropong tse ts'oeroeng li ile tsa sebelisoa haholo ke lisebelisoa tse fapaneng tsa matlakala, tse sebelisoang e le lisebelisoa tse fapaneng tsa motlakase, tse sebelisoang e le lisebelisoa tse kopaneng tsa motlakase Lisebelisoa tsa ho lokisa microcapsules tse tšehelitsoeng; E ka sebelisoa hape e le thepa ea boipheliso molemong oa ho hlophisoa ha batho ba thata; E sebelisoa haholo theknoloji ea pharmacceutical joalo ka ntho e etsang ntho e etsang filimi le ho koaloa ha lifilimi, hammoho le sefifi. Joaloka mokhabo o sirelletsang oa letlapa, ho ka fokotsa ho hlonama le ho thibela moriana ho angoa ke mongobo ebe ho thibela lithethefatsi ho angoa ke mongobo oa mongobo, ho hlokahatsana le ho fokola; E ka theha lepotlapotla la limpho tsa GEL, Liphoofolo tse nang le sefepo, li thusa mothehi, 'me u nolofalle ho lokolloa ha moriana o matla.
Lahla likopo tsa ho qetela le ho potlakisa phetoho le ntlafatso
Ka kakaretso, metsi-so Solillase Sodium Celllolose, Methroxypropty Methylpropty Litokisetso, li-agency tsa ho etsa lifilimi tsa lifilimi, lisebelisoa tsa capleule le li-agente tse sa khoneheng. Ha u sheba lefatše, lik'hamphani tse 'maloa tsa machabeng tsa kantle ho naha (Shin-etsu Japan, Dow Wolfe le Asland Kenya kopo ea kopo kahare. Dow Wolfe e phatlalalitse hore e tla matlafatsa tsepamiso ea eona ho thetso, mefuteng ea meropa ea China ea mananeo a China le eona e tla loanela ho atamela 'marakeng. Dowmf Colff Colff Cellingsf Collulose Bopaki ba Kopano ea United Lefatšeng, ka Litsi tsa Boithuto ba Lipatlisiso bo Ngotsoeng As A. Kunjing, Changzhou, Kunjing, Kunjing, Kunjen le Riiang
Ho latela lipalo-palo webosaeteng ea China Cell Mokhatlo oa Machalo Ether e neng e le malapeng e ne e le lithane tse 373 000. Ka 2017, boholo ba thekiso ea Ionic cmc e ne e le lithane tse 234 000, keketseho ea selemo sa 18,61, keketseho ea lihora tse 86% ea selemo sa 8,2. Ntle le HPMC (lihlahisoa tse se nang ioyc), HPMC (Pharmac (Kereiti ea Liphoofolo) Leha ho le mashano a lapeng Ether e 'nile ea hola ka potlako ho feta lilemo tse leshome,' me tlhahiso ea eona e se e le ea pele lefatšeng. Leha ho le joalo, lihlahisoa tsa lik'hamphani tsa lik'hamphani tsa khetla e ngata ea selefoulo li sebelisoa haholo libakeng tse bohareng le tse tlase tsa indasteri, mme boleng bo eketsehileng ha bo phahame.
Hajoale, li-cellulard e ngata ea lapeng ether li le maemong a makatsang nakong ea phetoho le ntlafatso. Ba lokela ho tsoela pele ho eketsa boiteko ba ho etsa qeto le ntlafatso ea sehlahisoa, ba ka sebelisa ka botlalo le ho ntlafatsa sebaka sa indasteri le ho qetela.
Nako ea poso: Jun-15-2023