Hobaneng cellulle

Ho hlohlona ka phetolelo ke litheolelo le tse ling tse sebelisitsoeng ho tlhahiso le ho atolosa lithethefatsi, ke karolo ea bohlokoa ea mekoloto ea mekhahlelo ea meriana. Cemlulo Slllulose Ether le Ether Litlhaloso tsa meriana. Hajoale, boholo ba lihlahisoa tsa likhoebo tsa lapeng ether li sebelisoa haholo indastering, indasteri e hloka ho fetoha le lihlahisoa tse phahameng haholo.

Mekhabiso ea 'maraka ea Phatlalatso e kholo

Bareki ba pharmacetic ba bapala karolo ea bohlokoa ho nts'etsopele le tlhahiso ea tlhophiso ea meriana. Ka mohlala, litokisetso tsa ho lokolla - li-cap tsa khoele ea li-pelmacent, litokisetso tse fapaneng tsa phallo, litokisetso tse matla tsa ho lokolloa le litokisetso tse bolokiloeng. Tsamaisong ena, cellulolose Ether le polymer e meng ka kakaretso e sebelisoa e le thepa ea lithethefatsi ho laola sekhahla sa ho thibela lithethefatsi ka nako e itseng ho fihlela sepheo se sebetsang.

Ho latela lipalo-palo tsa lefapha la Zhiyanan le Patlisiso, mefuta e fetang 3000), mefuta e fetang 3000 e ntse e fokola, China e ntse e rehahame Ho utloisisoa hore li-rathmaties tse leshome tsa bolisa ba China ke PharmacEucal Glatin Celcolo, PPC

Tse tšeletsengMefuta eaCellulose EtherhoLitlhaloso tsa Phatlalatso

Natural conluulose ea tlhaho ke alkali cellengse ea alkali, ke celmolese hydrolecle ether Cellulose Ether o sebelisoa haholo peteroleum, thepa, lijo, mefuta eohle ea lingaka le likarolo tse ling tse eketsang. Ka lebaka la litlhokahalo tsa boleng ba boleng, tlhahiso ea meriana ea meriana e ka etsahala, ho ka thoe boleng ba lihlahisoa tsa sehlopha li ka emela matla a tekheniki a likhohlong tsa likhoele tsa cellulose. Hangata cellulolose e sebelisoa e le sebapali sa Skeleton, Skeleton

Sodium cisboxeMethyl cellulolose

Sodium celboxeMethyl Cellulose CMC-na ke mofuta oa mofuta o tloaelehileng oa meriana, o sebelisoang joalo ka li-khalase tsa litokisetso tse matla, hammoho le matrix ea metsi le filimi e khethollang thepa. Ka ho tsamaea butle (tse laoloang)

Ntle le sodium cilboxemesethyl cellulose Croadlin canboxelinemes, Canmc-na) ke metsi a hloekisitsoeng a carboxeMest Moemeli oa lifapano oa sefapano e ka sebetsa, e ka a moenthela, anipydride e anhydride le adisi ea ashhydride. Closslin canboxelingethyl celbolose e sebelisoa e le moemeli oa matlapa, khaleliloeng ho ba le mokhoa oa ho qhalana ka molomo, ka bora ho ba le metheo ea ho qhala, ho futhumatsa matla a ho tela. Boithuto bo bontšitse hore tekanyo e ferekang sodium canboxelist e kholo ho metsi e kholo le lisebelisoa tse ling tse tloaelehileng tsa Hydrate.

Methyl celluloulose

Methyl cellulose (MC) ke 'mala o le mong ea sa rateheng o entsoeng ho tsoa ho k'hothone le lehong ke maskalization, li-aditthane tse ling. Methyl cellulose e na le soloulose ea metsi a mafura a metsi mme e tsitsitse ho ph bla le 2.0 ~ 13.0. E sebelisoa haholo ho li-emplets tse tlase, litokisetso tsa instralcular, li-capsulmic lila, matlapa a molomo le litokisetso tsa molomo le litokisetso tsa molomo le litopo tsa molomo. Ntle le moo, MC e ka sebelisoa e le tokiso e ileng ea qholotsa lintho tse ileng tsa loanela ho phela ka mokhoa o tsitsitseng ea ho tsamaisa thepa, ho lokolloa lintho tse ngata tsa bongaka tsa lifilimi, e leng

HydroxypropypropyLe cellulolose

HydroxypropypropypropinyL methyl cellulolose (HPMC) ke selefou e sa rateheng e entsoeng ho tsoa ho k'hothone le lehong tsa maskalization, propylyute ea chloromethane. Ha e na mokhoa o mongata, o sa tsitsa, o qhibilihang ka metsing a batang le a gelatin ka metsing a chesang. HydroxypropypropypropypropinyL methyl, litekanyetso le boleng ba li-cellulolo ho tseno tsa cellulose malapeng le kantle ho naha, e le lilemo tse ka bang 50. Hajoale, kopo ea HPMC e bonahala haholo likarolo tse ling tse latelang:

E 'ngoe e tšoana le moemeli oa tekano le ea sa tsotelleng. HPMC ha e le morui e ka etsa hore lithethefatsi li be metsi, 'me metsi a sona a ka holisa linako kapa ho lokolloa hoa matlaka. HPMC e na le lipono tse matla, bakeng sa mokhoa oa crisp kapa thepa e thata e ka ntlafatsang setšoantšo sa eona, ntlafatsa tumello ea eona. HPMC Viscosity e ka sebelisoa e le moemeli oa tekano le ea sa tsotelleng, viscosess e phahameng feela e le moqapi.

Ea bobeli e joalo ka thepa e liehang le e laoloang e koahetsoeng ka potlako bakeng sa litokisetso tsa molomo. HPMC ke lisebelisoa tsa mofuta oa hydrogel li sebelisoa hangata litokisetsong tse lokollotsoeng. HPMC e nang le maemo a tlase a Viscosity (5 ~ 50Maf. HPMC e ka qhibiliha mokelikeli oa maastric, e na le melemo ea ho tobana le pherekano e matla ea phepelo ea phepelo ea hydrophili e lulang e tsitsitse, 'me e sebelisoa ke li-hydrophili tsa hydrophili ea hrropection, joalo ka lisebelisoa tsa ho lokolloa tsa hydrophili e tsejoang.

Taba ea boraro, joalo ka filimi ea koae - e theha moemeli. HPMC e na le filimi e ntle, e etsa baesekopo ea baesekele, lithethefatsi tse sa tsitsang, haholo-holo ha ho sa khone ho ntlafatsa lithethefatsi, ho thibela tlhahiso ea lifilimi. HPMC e na le litlhaloso tse fapaneng tsa lipolelo tsa pono, joalo ka khetho e nepahetseng, boleng ba lifilimi, ponahalo e molemo ho feta lisebelisoa tse ling, tse sebelisoang khafetsa ho sebelisoa 2% ~ 10%.

Ea bone e joalo ka lisebelisoa tsa cappule tsa cappule. Lilemong tsa morao tjena, ka ho phatloha ha seoa sa liphoofolo lefatšeng ka bophara, ha ho bapisoa le li-capsules tsa Getatin, li-capsul tse ncha tsa khoebo ea pharmaone le lijo. Pfizer e atlehile ho tsoa ho HPMC ho limela tsa tlhaho le li-capsules tsa limela tsa VCAPTM. Ha ho bapisoa le li-capsules tsa setso tsa Getatin Sekhahla sa ho lokolloa ha sethethefatsi se tsitsitse, liphapang tsa motho ka mong li nyane, 'me ha li kenelle ka lebaka la ho nyelisa' mele oa motho, 'me li ka lokolloa' meleng ka makhopho. Mabapi le maemo a polokelo, ka palo e kholo ea liteko, li-capsules ha li na ho brittle maemo a mongobo, 'me tikoloho ea li-capsules e tlase,' me li-capsues tsa li-capsules li ntse li le tlas'a maemo a eketsehileng a polokelo. Ka kutloisiso ea batho ba li-capsules tsa batho, hammoho le phetoho ea mohopolo oa lithethefatsi lapeng le kantle ho naha, ho batla li-capsule tsa li-capsule tsa lema ka potlako.

Tse hlano e le moemeli ea emisitsoeng. Litokisetso tse emisitsoeng tsa metsi li ile tsa sebelisoa hangata liforomo tsa litekanyetso tsa setso, e leng litsamaiso tse sa tsitsang tsa lithethefatsi tse sa feleng. Ho tsitsa ha sistimi ho khethoa boleng ba tokiso e emisitsoeng. Tharollo ea coloidal ea HPMC e ka fokotsa khatello ea metsi e tiileng, e fokotsa matla a se nang moeli, e le hore tsamaiso ea heterognone e batlang e tsitsitse, ke moemeli ea emisang. HPMC e sebelisoa e le thipa ea mahlo a mahlo, 'me litaba ke 0.45% ~ 1.0%.

Contlase ea hydroxypropyl

HydroxypropypropyL ke celluulose (HPC) ke Ether e le 'ngoe e sa rateheng e entsoeng ho tsoa ho k'hothone le lehong ke maskalization, lisebelisoa tse ling le lits'ebetso tse ling. HPC hangata e qhibiliha ka metsing ka tlase ho 40 ℃ le palo e kholo ea li-qluces tse kholo. Litsi tsa eona li amana le litaba tsa cydroxypropyl le degree ea polymerication. HPC e ka lumellana le lithethefatsi tse fapaneng 'me e na le kahare ho kahare.

BydroxypropypropyLel celluulose (L - HPC) haholoholo bakeng sa ho senya le ho khothatsa tšusumetso e phelisang.

HeldroxypropypropyLel celluulose e ka sebelisoang e le binder bakeng sa letlapa, granule le granule e ntle tšimong ea meriana. H-HPC e theha sehlahisoa se ratehang, filimi e fumanoeng e thata ebile e bapisoa ebile e bapisoa le polasetiki. Ka ho kopanya le baemeli ba bang ba anti-mongobo, ts'ebetso ea lifilimi e ka ntlafala, 'me e sebelisoa hangata e le thepa ea lifilimi bakeng sa litafole. H-HPC e ka sebelisoa e le litaba tsa moralo ho lokisa lipatsi tsa matlakala-tokiso, li-pellets tse lebelo le litafole tse peli tse tobileng.

Hydroxeeyl cellulosese

Hydroxethyl celdlosese (Hec) ke Ether e le 'ngoe e sa lumellaneng le Cellulose Hec o sebelisoa haholo e le bolotsana, moemeli ea sireletsang o sirelelitsoeng, a khomareloang, a hlolloang, a hlohlelletsa Moemeli le ho lokolloa - lefapheng la tokoloho ea bongaka. E ka sebelisoa ho tsuba tsa lithethefatsi tsa lehae, li-olanete, marotholi a mahlo, metsi a mahlo, matlapa a tiileng, li-capsules le liforomo tse ling tsa litekanyetso. Hydroxethyl celdoulose e kenyellelitsoe United States Pharmakopoe / United States Sechaba sa Naha le Europe.

Sesebelisoa sa Ethyl

Sesebelisoa sa Ethyl (EC) ke e 'ngoe ea libui tse sebelisoang haholo tsa metsi. EC ha e chefo ebile e tsitsitse, a asitiana kapa tharollo ea asiti, asiti, a qhalaneng, methanol le li-solvents tse ling. Li-so solven tse tloaelehileng ke motsoako oa Toluene / Etanol motsoako oa 4/1 ka boima. EC e na le ts'ebeliso e mengata ea tšebeliso ea lithethefatsi tse laoloang ke lithethefatsi tse laoloang ke mefuta e mengata ea li-skeleton. micro capsule; E ka sebelisoa hape e le thepa ea motho ea belang motho ea nkang ho hasoa ka thata. E sebelisoa haholo theknoloji ea pharmacceutical e le filimi e thehang ntho le ho atoloha ho alima, hammoho le binder le filimi. Joaloka mokhabiso o sirelletsang oa matlapa a matla, a ka fokotsa ho hlonama le ho thibela meriana ea matlakala ho thibela meriana ea matlakala ho angoa ke mongobo le ho ferekana. E ka theha lerathe e tsamaeang butle butle ebe e emisa polymer e nang le microcapsules, e le hore phello ea lithethefatsi e ka nkoa e sa sebetse hantle.

Re tla tlosa likopo tsa mahareng le tse tlase le ho potlakisa phetoho le ntlafatso

Ho akaretsa, metsi a qhibiliha ka metsing Sesebelisoa sa capPule le lithuso tse emisitsoeng tse sebelisoang ho li-raricaints tsa meriana. Ha a sheba lefatše, lik'hamphani tse 'maloa tsa machabeng tsa kantle ho naha (Japan Shin, kapa Ashland, a eketsa matsete a phatheneng lebaleng lena. Dow o phatlalalitse hore e tla nyoloha ho tsepamisa maikutlo hodima mefuteng, metsoako le litlhoko tsa 'maraka oa China, hammoho le boiteko ba ona ba ho tlisa lipatlisiso tse fumanehang haufi le' maraka. Karolo ea Discoulose Aroul le mebala ea Cellulose e thehile tumellano ea lefatše bakeng sa liforomo tse fetang 1,2 200 ka lik'hamphani tse 15 tsa lipatlisiso tse sebeletsang linakeng tse ka bang tse 160. Ashland e na le li-asland tse fumanehang Beijing, Shanghai, Shanghai, Changzhou, Kunjen le Riiang

Ho ea ka sebaka sa marang-rang sa setsoalle sa China Mokhatlo oa China e rekisitsoeng e ne e le lithane tse 373 000 tse 380,000. Ka 2017, boholo ba thekiso ea Ionic cmc e ne e le li-ins tse 234 000, 'me tse sa sebetseng hantle li ne li le lithane tse 126,000, tse holimo selemong. Lihlahisoa tse seng tsa Ionic ho kenyelletsa HPMC (lisebelisoa tsa moaho), Promaceutical), PPMC, FOS) Banana ba lapeng Ether e 'nile ba hola ka potlako, empa boholo ba lihlahisoa tsa khoebo tsa batho ba nang le chelete e ngata li sa phahame.

Barekisi ba fapaneng ba Cellulose Ether ba le linaheng tse ling, haholo-holo ka lebaka la phetoho ea lihlahisoa, ba etse hore khoebo e phethe haholo, e be e matla lebaleng la indasteri le nts'etsopele ea Green.