Methyl celluloulose (MC) le hydroxyproppyl methylcelllfillose (HPMC) ke litlolo tsa celloulose 'me li sebelisoa haholo ho li-methmaneutical, lijo, thepa e' ngoe. Le ha tsona li tsoa ka mpeng ea tlhaho 'me li na le tšebetso e tšoanang likolong tse ling, ba na le liphapang tsa bohlokoa likolong tsa lik'hemik'hale, thepa ea sebetsang, masimo a sebetsang.
1. Sebopeho sa lik'hemik'hale le ts'ebetso ea ho hlophisa
Methyl celluloulose (MC) Ka ho khetheha, lihlopha tsa hydroyl celdlese li sebetsana le litšitiso tse ngata (joalo ka methyl chloride) tlasa maemo a lithyline. Ka lebaka la likhato tse fapaneng tsa sebaka, MC e ka ba le kutloano e fapaneng le pono.
HydroxypropypropinyL methylcelllulose (HPMC): HPMC e fetotsoe motheong oa Mc, eseng feela sehlopha sa Hydroxypropy (-ch₂chohch₃) Hydroxy. Ho hlophisoa ha HPMC ho kenyelletsa karabelo ea mehato e 'meli: pele karabelo ea kelello ebe u ikutloa joang ka mokhoa oa hydroxypropyproppy. Ka lebaka la ho nkeloa sebaka seo habeli, thepa ea HPMC e rarahane haholo ebile e fapane.
2. Thepa le Metsi a Furiloeng
SELUBUBILE ea MC: Methylcelluse e na le lisosa tse ntle ka metsing a batang, empa ha e qhele metsi a chesang. Tharollo ea eona e tla hlahisa ketsahalo ea GEL ha e futhumatsa, e etsang hore MC e na le boleng bo ikhethang ba ts'ebeliso tlasa maemo a teng.
SELUME ea HPMC: Ho fapana le moo, HPMC e qhibiliha metsing a batang le a chesang, 'me litharollo tsa tsona li na le mefuta e pharalletseng ea litaba. Ntle le moo, HPMC e bonts'a botsitso ba ho tsitsa ba WWIONS 'me ha ba amehe ho liphetoho boleng ba PH, ka hona e sebelisoa indastering ea meriana le ea lijo.
3. Libaka tsa kopo
Ts'ebeliso ea Methylcelllubulose: Ka lebaka la thepa e futhumatsang ea MC, hangata e sebelisoa e le metsi indastering ea kaho, haholo-holo sere sa kaho, haholo-holo sere sa kaho, haholo-holo sere sa kaho, haholo ho thusa ho ntlafatsa tatso le botsitso ba lijo. Likhopang tsa meriana, ka linako tse ling li sebelisoa e le moemeli oa ho etsa matlapa le thepa ea lifilimi bakeng sa li-capsules.
Likopo tsa Hydroxypropyl MethylcellOlose: HPMC e tenyetsehe ho feta MC ho indasteri ea eona ea ho pharalla le botsitso. Mohlala, HPMC e sebelisoa haholo indastering ea meriana le likheo tse tobileng le capleule, hape e le thipa le lubricant litokisetso tsa litoto tsa mahlo. Ka lisebelisoa tsa kaho, li-hpMC li sebelisoa e le moemeli oa bolotsana le metsi bakeng sa liphiri, likhohola le liriti le lits'oants'o le lirifi. Ntle le moo, HPMC e sebelisoa e le thippner, emmolifier le hlonali ea indastering ea lijo.
4. Likarolo tsa ts'ebetso le liphapang tsa tšebetso
Litšobotsi tse sebetsang tsa MC: Karolo e ikhethang ea methylcellllulose e futhumatsang ea eona e tukang, e etsang hore e be e tsitsitseng likopo tse hlokang ho tsitsa. Ntle le moo, tharollo ea aquazy ea MC e na le tekanyo e itseng ea pepenene le ketsahalo e kholo, e leng molemo lits'ebetsong tse ling tsa indasteri.
Litšobotsi tse sebetsang tsa HPMC: HydroxypropyproppyL methylcelubulo e tšoauoang ke ho se sebetse ha eona le tharollo ho mocheso le ph. Litšobotsi tsena li etsa hore HPMC e bontše maemo a maholo le botsitso lits'ebetsong tse fapaneng. Ntle le moo, biocompatian ea HPMC le chefo e bohlokoa haholo ho indastering ea bongaka le ea lijo.
5. Tšireletso ea tikoloho le polokeho
Thepa e ntle ea tikoloho ea MC le HPMC: Ha e ntse e etsa lintho tse ngata, MC le Hpmc ke lisebelisoa tsa biodegradadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadad Ntle le moo, lisebelisoa tsena ka bobeli hase ntho e nang le chefo, e seng tse khopisang ebile e bolokehile haholo, e etsang hore li sebelisoe libakeng tse nang le kamano e phahameng ea batho, joalo ka lijo le meriana.
Le ha methylcelllllllulose (Mc) le hydroxyproppyLopyLyproPullow (HPMC) le thepa ea bona ea lik'hemik'hale le litšobotsi tsa kopo li fapane ka lebaka la tse ling tse fapaneng. Ho na le liphapang tsa bohlokoa. Mc Haholo-holo e ipabole likopo tse hlokang thepa ea litlokotsehale tse futhumatsang, joalo ka thepa ea ho haha; Ha HPMC e sebelisoa hohle ho li-pharmaconetics, lijo le tsa kaho ka lebaka la tharollo ea eona e ngata, botsitso le chefo. Ho utloisisa liphapang lipakeng tsa tse peli ho ka u thusa ho khetha thepa e loketseng haholo bakeng sa ts'ebeliso e itseng.
Poso: Hlakubele-17-2025