HydropitypropiypropinyLuloseth (HPMC) ke poto ea pona e thehiloeng ka mpeng e sebelisitsoeng tšimong ea meriana ea meriana, haholo nts'etsopele ea litsamaiso tsa hydrophilic matrix. Litsamaiso tsena tsa Matrix li bohlokoa bakeng sa ho laola tokollo ea metsoako e sebetsang ea meriana (APIS) ka tsela e laoloang le e tsitsitseng. HPMC e fumaneha ka limaraka tse fapaneng tsa lipapatso, li lumella litsebi tsa liphallelo, meriana ea meriana ho tsamaisa thepa ea mochini o tobileng oa lithethefatsi.
1. Selelekela ho HPMC POYTM
Tlhaloso le sebopeho
HPMC ke polymer ea se nang moea e qhibilihang ea metsi e tsoang cellulose. E na le likarolo tsa 2-hydropyl le methyl tse pheta-pheta liuniti tse kentsoeng ho sekhutlo sa mokokotlo oa cellulose. Tekanyo ea lihlopha tsena e ama thepa ea HPMC, ho kenyeletsa le litsietsi tsa eona, liketsahalo tsa eona le bokhoni ba ho itsamaisa.
2. Karolo ho litokisetso tsa meriana
HPMC e na le melemo e 'maloa e le e hlomphehang ka litlhahiso tsa meriana. Mofuta oa eona oa hydrophilic o etsa hore o tšoanele tšebeliso ea litsamaiso tsa hydrophilic matrix Sebopeho sena se laola tokollo ea moriana, e fana ka litlamorao tse tsitsitseng tsa kalafo le nako e telele.
3. Liphetoho mo Keneng oa Viscosity
Bohlokoa ba Viscosity
Viscosity ke paramente e nyarosang ea litlhare tsa meriana e sebelisang HPMC. E etsa qeto ea litšobotsi tsa phallo, boiketlo ba ho sebetsa le ho lahleheloa ke litšobotsi tsa lithethefatsi ho tloha tsamaisong ea matrix. Mabaka a fapaneng a HPMC a na le li-viscosion tse fapaneng, 'me litsebi li ka tiisa thepa ena ho latela litlhoko tse ikhethang tsa moriana le profil e lakatsehang.
Litlhaloso tsa liketsahalo tsa Viscosity Creecer
Khetho ea sehlopha sa pono ea HPMC se ipapisitse le lintlha tse kang sello sa lithethefatsi, sekhahla se lakatsehang sa tokollo, foromo ea litheko le ts'ebetso ea litheko. Mera e ka tlase e ka tlase e ka ba e loketseng ho lokolloa ka potlako, ha limaraka tse phahameng tsa lipapatso li fana ka tokollo e matla.
Tekanyetso ea Rispepe
Ho fumaneha ha mefuta ea mefuta ea li-viscosity e ntlafatsa maemo a matlafatsang ka ho qapa liforomo tsa meriana. Ho feto-fetoha ha maemo ho bohlokoa ho amohela thepa e fapaneng ea lithethefatsi le ho ntlafatsa ts'ebetso ea kalafo ea sehlahisoa sa ho qetela.
4. Phello mabapi le li-curve tsa lithethefatsi
Ho lokolloa ha lithethefatsi tse laoloang
Litsamaiso tsa HPMC matrix li sebetsa ka molao-motheo oa phepelo le sebopeho sa GEL. Ha matrix a kopana le metsi, a abelana le ho etsa sekala sa gel ho potoloha le likaroloana tsa lithethefatsi. Setlhare se lokollotsoe ka lebaka la phapang le khoholeho ea mokato oa gel. Ho fetola pono ea HPMC ho lumella taolo e nepahetseng ea sekhahla le nako ea tokollo ea lithethefatsi.
Litokiso tse Khothalelitseng
Mefuta e phahameng ea liforomo tsa HPMC hangata e sebelisoa ho nts'etsopele ea liforomo tse lebelo. Hangata mehopolo ena e etselitsoe ho lelefatsa khafetsa ho etsa liphetoho khafetsa le ho ntlafatsa ho latela mamello.
5.Kaholations tsa 10.
LITLHAKISO
Ho khetha sehlopha se loketseng sa pono ea HPMC le sona se susumetsoa ke ho etsa tlhahiso. Meraka e phahameng ea li-viscosuoty e ka baka mathata nakong ea ts'ebetso, joalo ka linako tse eketsehileng tse kopanyang le teka-tekano ea lichelete. Ma-fordilator e hloka ho hlakisa chelete lipakeng tsa ho fihlella profil ea lithethefatsi tse lakatsehang le ho netefatsa hore ts'ebetso ea ho etsa lintho.
Ho lumellana le batho ba bang
Hpmc hangata e sebelisoa hammoho le tsebiso e ngoe ho fihlela lipheo tse ikhethang. Ho lumellana ha libaka tse fapaneng tsa viscosity tse fapaneng le tse ling tse nang le tsebo e bohlokoa ho netefatsa ho tsitsa le ts'ebetso ea foromo ea ho qetela ea dosage.
Ho latela maikutlo a ho latela melao
Makhoma a lithethefatsi a tlameha ho kopana le litekanyetso tsa taolo ea taolo, 'me tšebeliso ea HPMC le eona e joalo le. Maqephe a HPMC a lokela ho khethoa ho latela litlhoko le litataiso ho netefatsa polokeho, katleho le boleng ba sehlahisoa sa pharmactiatic.
Lipokotho tsa HPMC li bapala karolo ea bohlokoa ntlafatsong ea litlolo tsa lingaka tsa hydrophilic matrix bakeng sa ho lokolloa ha lithethefatsi tse laoloang. Ho fumaneha ha limaraka tse fapaneng tsa viscosution ho feto-fetoha le maemo a ho fetolela lipapatso tsa lithethefatsi tse mabapi le thepa le liphofu tsa kalafo. Khetho e hlokolosi ea sehlopha se loketseng sa pono e bohlokoa ho fihlela ts'ebetso e lakatsehang ha e ntse e sebetsana le maikutlo a ho etsa tlhahiso le taolo. Joaloka lipatlisiso tsa lithethefatsi le nkmaisi e ntse e tsoela pele, HPMC li ka tsoela pele ho bapala karolo ea bohlokoa bophiong le nang le maikutlo a lithethefatsi.
Poso: Feb-19-2025