HydroxypropypropinyL methylcelllulose (HPMC) ke polyt e khelohileng e sebelisoa haholo ho li-pharmacleications, lijo, kaho, le indastering e meng e fapaneng. Metsi a eona a ikhethang a e etsa hore e be ea bohlokoa likolong tse tsoang lits'ebetsong tsa ho tsamaisa lithethefatsi ho ea li-agente tsa ho holisa li-agents tsa lijo. Ho utloisisa ts'ebetso ea tlhahiso le ho phalla ha hpmc ke ea bohlokoa bakeng sa ho netefatsa boleng ba sehlahisoa le botsiso.
1.Le khetho ea lintho tse bonahalang:
a. Mohloli oa Mohloli oa Cellulose: HPMC e nkiloe ho Cliloulose, hangata e na le li-pulp tsa lehong kapa lineton linces.
b. Litlhoko tsa bohloeki: Cellulose e phahameng ea bohloeki e bohlokoa ho netefatsa boleng ba HPMC. Litšitiso li ka ama ts'ebetso le thepa ea sehlahisoa sa ho qetela.
c. Degree of Sing: Baetsi ba lihlahisoa ba khetha cellulose ka maemo a nepahetseng a DS e loketseng ho ipapisitse le kopo e lakatsehang.
Karabelo ea 2:
a. Moemeli oa menyetla: propylene Oxide le methyl chloride e sebelisoang hangata e sebelisoa hangata tlhahisong ea HPMC.
b. Maemo Maemong a Boitšoaro: Karabelo ea phallo e etsahalang tlasa mocheso o laoloang, khatello le PH ho fihlela li-DS tse lakatsehang.
c. Catalysts: alkali catalys e joalo ka sodium hydroxide kapa potasiamo hydro chisi
d. Ho beha leihlo: Ho beha leihlo ho tsoelang pele ha lipapatso tsa karabelo li bohlokoa ho netefatsa boleng bo matla le boleng ba sehlahisoa.
3.Parization "le ho hlatsoa:
a. Ho tlosoa ha litšitiso: Lits'ebetso tsa ho itšireletsa tsa ho itšireletsa ho tlosa balumeli bao u sa bonahaleng, lihlahisoa le litšila.
b. Mehato ea ho hlatsoa: Mehato e mengata ea ho hlatsoa metsi kapa ea manyolo e etsoa ho hloekisa HPMC le ho fihlela boemo bo batlang bo hloekile.
c. Ho feto-fetoha le ho omisa: Ho sebelisoa mekhoa ea ho khetha hpmc
Taolo ea boholo ba 4.Partcle:
a. Ho seripa le milding: likaroloana tsa HPMC hangata li kentsoe likotsi le mekhoa ea lejoe la lepato ho laola ts'ebetso ea lintho tse tloaelehileng.
b. Ho hlaphoheloa: Mekhoa ea ho qala ho netefatsa ho etsa bonnete ba ho ajoa hangata le ho tlosa likaroloana tse ngata.
c. Mofuta oa karohano: Mekhoa ea tlhahlobo ea mahlale ea boholo ba
Ho kopa hape le ho theha:
a. Cleend Composition: HPMC e kanna ea lekana le e nang le litheolelo tse ling kapa li-adtivels ho tsamaisa thepa ea eona bakeng sa lits'ebetso tse tobileng.
b. Homogenization: Mekhoa e kopanyang e kopanyang e ntšetsa pele kabo ea HPMC ka har'a mefuta ea ho fihlela litšobotsi tse lakatsehang.
c. Ho theha ts'ebetso: Ho theha liratsoana tse kang HPMC
Taolo ea 6.qual:
a. Teko ea Tlhahlobo: Mekhoa e mengata ea tlhahlobo e kang Spectrascopy, chromatography, le Rheogy e sebetsa bakeng sa taolo ea boleng ba HPMC.
b. Boikemisetso ba DS: DS ea HPMC e lekantsoe khafetsa ho netefatsa litšebelisano le ho latela litlhaloso.
c. Tlhatlhobo ea ponno: Mekhahlelo e sa hlakang e hlahang, litaba tse thata tsa tšepe, le bohloeki bo boima ba tšepe li netefalitsoe ho netefatsa polokeho ea sehlahisoa le ho latela melao-motheo ea sehlahisoa.
7.Pekisang le ho boloka:
a. Lisebelisoa tsa ho paka: HPMC hangata e kenella mongobo o thibelang mongobo ho thibela litšila le ho boloka botšepehi ba sehlahisoa.
b. Maemo a polokelo: HPMC e lokela ho bolokoa tikolohong e omeletseng, e pholileng hole le khanya ea letsatsi ho thibela ho monya mongobo le ho senya.
c. Shelfofai: E bolokiloe hantle 'me e bolokiloe HPMC e ka ba le bophelo ba sekhukhu bo sa tsoa fihla likhoeling tse' maloa ho latela maemo a thetsi le a polokelo.
Mokhoa ona oa ho etsa HPMC o kenyelletsa letoto la mehato e hlalositsoeng hantle, ho tloha ho khetha khetho e tala ho sephutheloana sa ho qetela sa sehlahisoa. Karolo e 'ngoe le e' ngoe e hloka taolo e hlokolosi le ho lekola ho netefatsa boleng ba boleng, bo feto-fetohang le ho latela melao e laoloang. Ka ho ela hloko ts'ebetso ea ho etsa thepa le phallo ea HPMC, bahlahisi ba ka ntlafatsa ts'ebetso ea tlhahiso le ho kopana le litlhoko tse fapaneng tsa indasteri e fapaneng.
Poso: Feb-18-2025