Hydroxypropypropinyl MethylceLulose (HPMC) ke Likhetho tsa Polymer tsa tlhaho tse sebelisoang hangata lijong, meriana, litlolo le masimo a mang. Li etsahetseng ke sesupo sa bohlokoa se amang tšebetso ea sona, seo hangata se amanang haufi le lintlha tse amang maemo a kang boima ba 'mino oa HPMC, tharollo ea solvenc.
1. Boima ba Molek'hule
Boima ba limompecular tsa HPMC ke e 'ngoe ea lintlha tse fanoang ka ho fetisisa tse amang pono ea eona. Ka kakaretso, boima ba limok'hule, boima ba lisele tse kholo, tse telele tsa limomane tsa HPMC, ho hobe le ho feta ho phoka le ho feta tsa Viscoscity. Lebaka ke hobane sebopeho sa kemiti ea Macorromolecular se fana ka ts'ebelisano e 'ngoe e amanang le ho feta, e bakiloeng ke lithibelo tse matla ho phoka ea tharollo. Ka hona, ka mahloriso a le joalo, tharollo ea HPMC ka boima ba limolek'hule hangata ba bonts'a liketsahalo tse phahameng.
Keketseho ea boima ba limok'hule e boetse e ama thepa ea li-Viscoelastic ea tharollo. HPMC Tharollo e nang le boima ba limolecular e phahameng e bonts'a li-incoselalasela tse matla ha li ka tlase, ha li ntse li ka itshwara ka maro a masela a bocha. Sena se etsa hore HPMC e be le boits'oaro bo rarahaneng bo rarahaneng maemong a fapaneng.
2. Tharollo ea Tharollo
Khatello ea tharollo e na le phello e kholo ho li-viccosōng tsa HPMC. Ha ho tsepamisa maikutlo ha HPMC hoa eketseha, tšebelisano lipakeng tsa limolek'hule ka tharollo e eketsa, ho baka ha ho hanyetsa ha ho hanyetsa liketsahalo tse ngata haholo ebe ke litšoantšiso. Ka kakaretso, ho tsepamisa maikutlo ha HPMC ho bonts'a kholo e senang palo e itseng, ke hore, tekanyo eo pono ea liketsahalo e emeng ka eona butle-butle e tsamaea butle butle.
Haholo-holo ka litharollo tse phahameng tse phahameng, tšebelisano lipakeng tsa liketane tsa molek'hule e le matla, le meaho ea marang-rang e ka ba teng, e tla eketsa pono ea tharollo. Ka hona, ho etsoa likopanong tsa indasteri, e le ho fihlela taolo e loketseng ea pono, hangata ho hlokahala hore u fetole khatello ea HPMC.
3. Mofuta oa solvent
Khoebo le pono ea HPMC e boetse e amana le mofuta oa solvent. HPMC hangata e sebelisa Meeponte joalo ka maemo a itseng a itseng, li-solvent tse ling tse kang Entono le amora li ka sebelisoa. Metsi, joalo ka solvent ea Polar, e ka sebelisana le lihlopha tsa hydroxyl le tsa methyl ho khothaletsa ho khesoa ha eona.
Tlhaselo ea Polavent, mocheso, le tšebelisano lipakeng tsa liliba tsa solvent le limolek'hule tsa HPMC li tla ama lillo le pono ea HPMC. Mohlala, ha solvent e potlakileng e sebelisoa, e lenliloeng ea HPMC e fokotsehile, e bakoang ke pono e tlase ea tharollo.
4. Mocheso
Kameho ea mocheso ke bona pono ea HPMC le eona e bohlokoa haholo. Ka kakaretso, Viscostoity ea tharollo ea HPMC e fokotseha ka mocheso o ntseng o eketseha. Lebaka ke hobane ha moqolo ona o ntse o eketseha, molecar ea molelo ea mosifari ea eketseha, ho fella ka ho fokolisa tšebelisano lipakeng tsa limolek'hule, ka tsela eo a fokotsa pono.
Ka mocheso o itseng, thepa ea rheological thepa ea litumellano ea HPMC e bonts'a boitšoaro bo totobetseng, ke hore, Viscos ha e angoe feela ke liphetoho tsa mocheso. Ka hona, likopo tse sebetsang, ho laela hore ho be le liphetoho tsa mocheso ke e 'ngoe ea mekhoa e metle ea ho fetola pono ea HPMC.
5. Tekanyo ea Shear
Litaba tsa tharollo ea HPMC ha li anngoe feela ke lintho tsa seoa, empa hape le sekhahla sa shear. HPMC ke mokelikeli o seng mocha, 'me lintho tsa eona li fetoha le phetoho ea sekhahla sa shear. Ka kakaretso, tharollo ea HPMC e bonts'a litšoantšo tse phahameng ka litefiso tse tlase, ha viscootions e fokotsa haholo ka litefiso tse phahameng haholo. Mona ketsahalo ena e bitsoa Shear Kholo.
Kameho ea sekhahla sa shear seleng ea tharollo ea HPMC hangata e amana le boits'oaro ba lipalesa tsa molek'hule. Ka litheko tse tlase, liketane tsa molek'hale li ratana, li fella ka pono e phahameng; Ka litekanyetso tse phahameng tsa tšepe, tšebelisano lipakeng tsa liketane tsa molek'hule e robehile 'me pono e lula e le tlase.
6. Boleng ba PH
Kelello ea HPMC e boetse e amana le boleng ba tharollo. HPMC MOELCOLES e na le li-hydropypropyl le lihlopha tsa methyl, 'me boemo ba lihlopha tsena bo angoa ke pH. Bophelong bo bong ba ph renges, hpm balecules ba kanna ba itahlela kapa ho etsa li-gels, ka tsela eo ka tsela eo, fetola pono ea tharollo.
Ka kakaretso, libakeng tsa acidic kapa tsa alkaline, sebopeho sa HPMC se ka fetoha, se amang tšebelisano ea eona ka limolek'hule tsa solt le, hape, li amang liketsahalo. Litekanyetso tse fapaneng tsa PH, botsitso le linyebelong tsa tharollo ea HPMC li ka boela li fapana, kahoo tlhokomelo e khethehileng e lokela ho lefelloa ho laola taolo ea phahlo nakong ea ts'ebeliso.
7. Matla a litlatsetso
Ntle le lintlha tse ka holimo, tlatsetso e itseng e kang letsoai le letsoai le ka tsona li ka ama pono ea HPMC. Ho eketsoa matsoalo hangata hangata ho a fetola matla a tharollo, ka hona a amang tharollo le pono ea limolek'hule tsa HPMC. Li-surfyants li ka fetola sebopeho sa limok'hule tsa HPMC ka ho fetola tšebelisano lipakeng tsa limolek'hule, ka tsela eo o fetola maikutlo.
Litaba tsa HPMC li angoa ke boima ba 'mino, ho kenyelletsa boima ba moleng, mofuta oa solvent, mofuta oa shear, boleng ba PH le li-blositive. Bakeng sa ho laola litšobotsi tsa liketsahalo tsa HPMC, lintlha tsena li hloka ho fetoloa ka nepo ho latela litlhoko tsa ts'ebetso ea sebele. Ka ho utloisisa lintlha tsena tse susumetsang, ts'ebetso ea HPMC e ka ntlafatsoa ho tlhahiso e fapaneng le maemo a tlase ho netefatsa boits'ireletso ba ona le katleho tse fapaneng.
Nako ea ho romella: Feb-15-2025