COPDROYPITPING ITHUTING

Li-capsules tse thata / hpmc how

Boikarabello bo Hlollang - Boithati ba ho etsa, ba ka boloka taolo ea mamello, lihlahisoa tse tiileng tsa molomo (OSD).

Ho li-actient tse 38 tse ncha tse nyane tsa molek'hule (nmes) tse amoheloang ke lijo tsa US le tsamaiso ea lithethefatsi ka 2019, 26 e ne e le Osd1. Ka 2018, lekeno la 'maraka le tšoaroang ka ts'ebetso ea bobeli ke CMONare' maraka oa Amerika o ne a tla tsoela pele ho hlola.

Matlapa a ne a ntse a laola 'maraka oa OSD, empa li-capsules tse thata li ntse li fetoha mokhoa o motle o ntseng o eketseha. Sena se kopanetsoe ka lebaka la ho ts'epahala e le mokhoa oa tsamaiso, haholo-holo tse nang le li-antitumor Apis. Li-capsules li ratana haholo ho bakuli, monko o sa thabiseng le litakatso tsa bohloko, 'me ho bonolo ho li metsa, haholo ho feta liforomo tse ling tsa litekanyetso.

Julien Lamps, mookameli oa sehlahisoa ho Capsules le metsoako ea bophelo bo botle, eba melemo ea bophelo ba Loonza O arolelana leseli la hae ho hydroxypropyl methylcelllulo (HPMC) e nang le sethethefatsi le kamoo ba ka thusang bahatelli ba bona ho meriana e nkileng meriana e nkileng meriana e nkileng meriana e nkileng meriana e nkileng meriana e nkileng meriana e nkileng meriana e nkileng meriana e nkiloeng ea limela.

Li-capsules tse thata: ntlafatsa ho latela tumelo le ho ntlafatsa ts'ebetso
Hangata bakuli ba loanela ho meriana e larileng kapa ho thata ho e metsa, kapa ho ka ba le litlamorao tse mpe. Ka kelellong, liforomo tsa litekanyetso tsa boits'oaro tse nang le maemo li ka ntlafatsa ho latela melao ea kalafo. Li-capsules tse thata ke khetho e ntle bakeng sa bakuli hobane, ka makhetlo a mangata a matheka, 'me li ka fetisoa ho lokolloa khafetsa, ka ho lokolloa ha lintšing tsa tokollo kapele.

Taolo e Ntle ho Boitšoaro ba Bokuli, Mohlala ka Micropeller The API, e ka thibela ho lahla le ho fokotsa leqeba. Bahlahisi ba lithethefatsi ba fumana se kopanyang mahlale a mangata ka li-capsules ho eketsa ho feto-fetoha ha maemo le katleho ea ts'ebetso ea API ea ho lokolloa. E ka ba ho ts'ehetsa li-pellets tse nang le apsi e fapaneng ka lehong le le leng, ho bolelang hore litheko tse fapaneng li ka fanoa ka nako e fapaneng ea tekanyetso.

Pharmacokinetic le litlhare tsa phapanyetsano ea liforomo tsena, ho kenyelletsa le tsamaiso ea li-multiparlic, 'me moqapi oa lefutso o ile oa etsa hore ho be le mekhoa e metle e bapisoang le eona.

Ke ka lebaka lena ntlafatso e ka bang teng ka mamello le katleho ea hore maraka a marako a hloka hore apis a aluloa ka li-capsufule tse thata e ntse e hola.

Khetho ea Polymer:
Tlhokahalo ea li-capsules tsa meroho ho nkela li-capsules tse thata tsa gelatin
Li-capsules tse thata tsa moetlo li entsoe ka Gelatin, leha ho le joalo, li-capsules tse thata tsa Gelatin li ka hlahisa mathata ha ho kopana le li-hygroscopic kapa tse hlokolosi. Gelatin ke sehlahisoa se nang le liphoofolo se kopanang le liphoofolo tse amanang le ho khelosa maikutlo, empa li na le seea se phahameng ho boloka metsi, empa hape e ka fapanyetsana metsi le apis le litheolelo.
Ntle le tšusumetso ea lintlha tsa kampo ea li-cappule ts'ebetsong ea Lihlahisoa, bakuli ba bangata ba leqe ho ipehela lihlahisoa tsa liphoofolo kapa tsa setso mme ba batla meriana e nkiloeng kapa ea vegen. Ho fihlela tlhoko ena, lik'hamphani tsa meriana le tsona li ntse li tsoela pele ho tsetela libakeng tse ncha tsa dosing ho etsa mefuta e meng e sireletsehileng ea limela e sebetsang le e sebetsang. Tsoelo-pele ea thepa e entse li-capsules tse tsoang malapeng tse ka khonehang, li fa bakuli khetho e seng ea liphoofolo - swalit ea li-captibule, le boitlamo ba litheko.

Bakeng sa ho qhalana le ho ikamahanya le ho khesoa:

Kopo ea HPMC

Hajoale, e 'ngoe ea mekhoa e meng e metle ea Gelatin ke hydroxypropyproppyl methylcellulose (HPMC), polymer e tsoa ho likhoele tsa sefate.

HPMC ha e na mokhoa oa lik'heneng ho feta Gelatin hape e amohela metsi a fokolang ho feta gelatin6. Maqhubu a tlase a li-capsules tsa HPMC li fokotsa phapanyetsano ea metsi pakeng tsa sehokelo le se maemong a mang, 'me a tobana le liphephetso tsa li-hygroscopic litsi le li-apis. HPMC Hollow Capsules ha e na kelello ho mocheso ebile ho bonolo ho boloka le ho tsamaisa.

Ka keketseho ea APIs e sebetsang hantle, litlhoko tsa lipalo li ntse li eketseha haholoanyane. Ho fihlela joale, baetsi ba lithethefatsi ba fihletse litholoana tse ntle molemong oa ho hlahloba tšebeliso ea li-capsules tsa HPMC ho nkela li-capsules tsa setso sa glatin. Ebile, li-capsules ha joale li khethoa ka kakaretso litekanyo tsa bongaka ka lebaka la ho tsamaisana hantle le lithethefatsi tse ngata le ho qhekella.

Lintlafatso tse tsoelang pele ntlafatso ea The HPMC Techsule le tsona li bolela hore baetsi ba litsebi ba khona ho nka monyetla ka lipampiri tsa eona tsa khefu tsa lefutso le ho kenyelletsa le lintlamo tse matla.

HPMC li-capsules ntle le moemeli ea nang le thepa e ntle ea ho qhalana hantle ntle le lits'ireletso tse tšoanang ha li atisa moriana ka mpa e le 'mala o mongata kapa le lijo. Joalo ka ha ho bonts'itsoe ho setšoantšo sa 1. 8

Ka lebaka leo, ntlafatso ea ho felisoa hoa ho felisoa ho ka lumella bakuli hore ba se ke ba tšoanela ho keketsa litekanyetso tsa bona, ka hona, ho latela melao ea bona ka hona.

Ntle le moo, tsoela pele ho nchafala ho HPMC COLULANESES Sin Stlhaloso ea Memmc ea Memmc

Taelo e 'ngoe ea kopo ea li-capsules tsa HPMC e maemong a ho hema bakeng sa tsamaiso ea pulmory. Tlhokahalo ea 'maraka e tsoela pele ho hola ka lebaka la phehe e ntlafalitsoeng ka ho qoba phello ea pele joalo ka ha ho na le lefu le sa lekanyetsoang la Asthma.

Bahlahisi ba lithethefatsi ba lula ba batla ho nts'etsapele kalafo e theko e boima, e nang le botsoalle le e sebetsang ea mafu a phefumoloho ea phekolo ea phekolo ea methapo ea kutlo. Tlhokahalo ea eketseha.

Lethathamo la metsi a tlase la li-capsules tsa HPMC li etsa hore li tšoanelehe bakeng sa li-hpgroscopic kapa li-li-opis tse thata ka ho nona, leha bokhoni ba motlakase ba tlameha ho nahaneloa ho pholletsa le nts'etsopele e teng.

Mehopolo ea ho qetela
Nts'etsopele ea Mabbrane ea Marang-rang le OSD ea OSD e behile motheo oa li-capsules tsa HPMC ho nkela li-capsules tse ling. Ho feta moo, ho halanela lintho tse ntseng li eketseha le ho batla litlhare tse theko e tlaase tse ntlafalitse tlhoko ea likhalase tse nang le mokhoa o ikhethileng ka limolek'hule tsa mongobo.
Leha ho le joalo, khetho ea thepa ea membrane ke eona ea ho netefatsa katleho ea sehlahisoa, le khetho e nepahetseng pakeng tsa Gelatin le HPMC li ka etsoa feela ka boiphihlelo bo nepahetseng. Khetho e nepahetseng ea lintho tse nepahetseng tsa Memdeane li ke ke tsa ntlafatsa ho sebetsa hantle le ho fokotsa karabelo e mpe, empa hape le thusa ho hlola mathata a itseng a sebopeho.