HyproylcluckpropyLulose (HPMC) le hypromelllose ke mantsoe a hangata a sebelisoang ka mokhoa o tšoanang, empa o bua ka ntho e tšoanang. HPMC ke mofoka oa maiketsetso oa cellulose, 'me hypromellose ke lebitso la machaba la cellulose (Inn) la motsoako ona. Hangata mantsoe ana a sebelisoa hangata indastering ea meriana le ea lijo, har'a ba bang, ka lebaka la maemo a ba sitisang a bona a fapaneng.
HydroxypropypropyLe methylcelll
Hydroxypropypropinyl methylcelulose ke selefounu e sentsoeng. Phetoho e kenyelletsa kenyelletso ea hydropypropyl le lihlopha tsa methola ho ea mokokotlong oa selefounu. Celluloselese ke polysaccharide e etsahalang ka tlhaho e kopaneng le likarolo tsa glucose e amanang le β-1,4-glycosidic. Kenyelletso ea hydroxypropyL (OHCH2ch (OH) CH3) LE LITLHAKISO TSE KHOLO (-Ka lihlopha li fana ka litsipe tse ikhethang tsa cellulose, lijuba tsa eona, li-viscity tsa eona.
Tekanyo ea sebaka (DS) e bua ka palo e tloaelehileng ea sebaka se ka bang sa anhydroglucose setulong sa ketane ea cellular. Tabeng ea HPMC, ho fapana ka DS ho ka baka limaraka tse fapaneng ka thepa e fapaneng, e ba etsang hore ba be le lisebelisoa tse fapaneng tsa likopo tse fapaneng.
Litšobotsi tsa hydroxypropyl methylcellubulose:
Sekhooa sa Fullubility le Gel:
HPMC e qhibiliha ka metsing ka lebaka la mocheso o pharalletseng, 'me alloubility a ipapisitse ka lintlha tse kang tekanyo e kholo ea boima ba lisele. Ho ba teng ha hydropxxxxypropyl le mekhoeng ea mekhoa e kenyang liluoeng ka metsing a batang, e etsang hore e tšoaneloe ke tšebeliso ka mefuta e fapaneng.
Viscosity:
E 'ngoe ea thepa ea bohlokoa ea HPMC ke bokhoni ba eona ba ho fetola pono ea tharollo. Maqephe a fapaneng a HPMC ka li-viscosion tse fapaneng li fumaneha ho latela litlhoko tse ikhethileng tsa Sebopeho.
Filimi e theha thepa:
HPMC e theha lifilimi tse hlakileng le tse feto-fetohang, ho e etsa ke tsa bohlokoa likoting tsa ho ikamahanya le indasteri ea meriana le ea lijo. Meru e etsang lifilimi e bohlokoa haholo ho tlhahiso ea liforomo tsa litekanyetso tsa molomo le ho koahela koae.
Stablize:
HPMC e bonts'a ho tsitsipanya holim'a mofuta o pharaletseng oa ph, ho kenya letsoho ho fapana hoa bona ka liforomo tse fapaneng. E hanela litlolo tsa enzymatic le tlhaselo ea boloi, e netefatsa botsitso ba lihlahisoa tsa meriana.
Litšireletso tsa meriana:
Coating Coating:
HPMC e sebelisoa haholo indastering ea meriana ea phatla ea lihlapi. Likomo tsa lifilimi li sebeletsa merero e fapa-fapaneng, ho kenyelletsa tatso ea ho alosa, ho sireletsa lithethefatsi ka mabaka a tikoloho le ho laola tokollo.
Litokiso tse Khopotso:
Ho laoloa le ho tšoareloang ho lokolloe lithethefatsi ke karolo ea bohlokoa ea ntlafatso ea lithethefatsi. HPMC e sebelisoa ho theha lits'ebetso tsa matrix tse lumellang ho lokolloa ha metsoako e sebetsang ea meriana (apis) nako e telele.
Litokisetso tsa Opphlhamic:
Lihlopheng tsa mahloriso, HPMC e sebelisoa ho eketsa pono ea li-drops tsa mahlo le nako ea ho ikopanya ha nako le sebaka sa ho kenella. Sena se ntlafatsa phello ea kalafo ea moriana.
Lipehelo tsa Tota le Transdermal:
HPMC e kenyelitsoe ka mekhoa ea lihlooho tse kang li-gels le li-tranelate ho fana ka pono le ho ntlafatsa monyetla oa ho nka sehlahisoa. E sebelisoa hape ho ea ho laola ho lokolloa ha lithethefatsi ka letlalo.
Metsi a molomo:
Hydroxypropypropinyl Methylcelulose e sebelisoa ho mefuta ea li-Fesage ea li-Ferage ea Methylcel.
Likopo tsa Lijo tsa Lijo:
Thckener:
HPMC e sebelisoa e le moemeli oa ho holisa lihlahisoa tse fapaneng tsa lijo, ho kenyelletsa leseces, liaparo le linokoane. Bokhoni ba eona ba ho fetola pono e thusa sehlahisoa sa ho qetela seo u se batlang.
Thckener:
Likoping tse ling tsa lijo, HPMC li ka sebetsa joaloka moemeli oa libini, tsa thusa ho etsa li-gels kapa li tsikitlanyetsa lihlong.
Khalase le likhetla:
HPMC e sebelisoa libakeng tsa lijo le lika-likele ho ntlafatsa ho latela moea, ponahalo le ho boloka mongobo. E theha filimi e pepeneneng e ntlafatsang boipiletso ba pono tsa lihlahisoa tsa lijo.
TLHOKOMELISO:
Ha hydrocolloid, hpmc e ka sebelisoa e le sebaka se mafura se nang le mafura kapa mafura a mahala, ho fana ka bosholu le lihlahisoa tse nang le mafura a nang le mafura a mangata.
Liphephetso le matšeno:
Ha Hydroxypropyl Methylcelulose
Maikutlo a mocheso:
Fulubility ea HpMC e anngoe ke mocheso. Liraro tse ling li ka tlosoa liahelo ka mocheso o phahameng, o hloka ho nahanela ka hloko ka tšebeliso.
Hygroscopic:
HPMC ke ho hloeka "hygroscopic, ho bolelang hore e ananele mongobo kamehla. Thepa ena e hloka ho nkuoa ke le lifoleng tse ngata tse nyarosang.
Ho nepahala ha lithethefatsi:
Ho lingaka tsa meriana, ho lumellana pakeng tsa lithethefatsi le polymer ho bohlokoa ho netefatsa botsitso le katleho ea sehlahisoa sa ho qetela.
Boemo ba taolo:
HydroxypropypropinyL methylcelulose e amoheloa haholo ke mekhatlo ea tsamaiso e kang limela le tsamaiso ea lithethefatsi tsa Europe (Ema). E thathamisitsoe ho livideo tsa seriti e le se neng se tsebahala ka litokisetso tsa meriana.
HypphiyproPypropyLulose, e tsejoang e le hypromellose, na le mokoetlisi oa machaba a nang le lits'ebetso tse fapaneng tsa meriana le ea lijo. Thepa ea eona e ikhethileng, ho kenyelletsa le lisoluulity, ho foqoha ha motho, bokhoni ba ho etsa lifilimi le botsitso, e etsetsana mefuta ea bohlokoahalikeng.
Ho tloha litabeng tsa matlapi le mererong e meholo ho meriana ho ba li-mericaners le lijalo tsa mafura a tsoang khoebong ea lijo, HPMC e phetha karolo ea lihlahisoa tsa bohlokoa ho ntlafatsa tšebetso le lihlahisoa tse fapaneng. Bokhoni ba ho tsamaisa thepa ea eona ka ho fetola boima ba ho lokisa boima le boselamose ho tsoela pele ka ho ikamahanya le maemo likoting tsa eona.
Poso: Feb-19-2025