Ethe ea bo-'mè ea selefouoeng ea cellular e feto-fetohang ka lik'hemik'hale tse kang tsa qhobosheane, ho etsa lifilimi, 'me li sebelisoa haholo indastering ea meriana. Ka lebaka la tšebeliso ea eona ea bioCompati ea eona le polokeho, liketsahalo tsa celluloulo li phetha karolo ea bohlokoa litokisetsong tsa meriana.
1. Lisebelisoa tsa matrix bakeng sa litokisetso tse sireletsehileng
Likhoebong tsa meriana, litokisetso tsa meriana tse laoloang ke sehlopha sa litokisetso tsa meriana tse patang katleho ea lithethefatsi ka ho lokolla lithethefatsi. Hangata e-ntshetsi-holo e 'ngoe e sebelisoa e le lisebelisoa tsa matrix tsa litokisetso tse sireletsehileng ka lebaka la lintho tseo a li khethileng' meleng le tsa lik'hemik'hale. Hydroxypropypropypropinyl Methylcelllulose (HPMC) ke e 'ngoe ea' nete e sebelisoang haholo ka ho fetisisa ea cellulose. E ka theha gel ka metsing mme e ka laola sekhahla sa lithethefatsi. Ka ho fetola Viscosty, ho na le maemo a ho ema le maemo a ho phumula, litšobotsi tse kholo tsa moriana li ka fetoloa ha ho hlokahala. Sena se etsa hore cellulose e-'mōtoana ea cellulose e etsa boitsebiso bo loketseng ba matrix bakeng sa tokollo e ts'ositsoeng, e laoloang e laoloang le litokiso tse atolositsoeng.
2. Likhalase tsa Letlapa
Tlalehong ea matlapa, ethe ea celluloulo Lae-rang e ka sebelisoa e le lithunya ho netefatsa hore e tsamaisoa ke lithethefatsi le matla a matla a matla. Haholo-holo ts'ebetsong ea moralo oa lipula, sodium celbolese (cmc-na) le hydroxypropypropyl cellulose Ntle le moo, ts'ebeliso ea Ethe ea bo-'mōpo ea cellulose e ka ntlafatsa ho kheloha ha matlapa, e le hore lithethefatsi li lokolloe kapele 'meleng le ho ntlafatsa binavaliple.
3. Sesebelisoa sa lifilimi se koahelang
E-'ethe-bo-'mè ba selefouso ba boetse ba sebelisoa haholo ka har'a likhetla. Joaloka lintho tse ka koahelang ho feta tsa hydroxypropyLe methylcelulose. Lifilimi tsa lifofane li ka boela tsa lieha ho lokolloa ha lithethefatsi ho fihlela litlamorao tse tsitsitseng. Ntle le moo, ka ho kopanya li-e-a ena le linyeoe tse ling, ho ba le mesebetsi e fapaneng ea ho lokolloa, bosholu ba ho lokolloa, joalo ka litlhoko tsa lithethefatsi tse fapaneng.
4. Li-thickeners le basetlelli
Litokisetso tsa metsi, li-sulpensions le ho thibela, ena-bo-'-bo-'-bo-'-ntoeng ba bapala karolo ea bohlokoa joaloka li-thickeners le ba tsibetsang. E ka eketsa tlhahlobo ea tharollo le ho ntlafatsa ho emisa lithethefatsi, ka ho tsuba ka mokhoa o ts'oanang le botsitso ba moriana. Ka mohlala, litokisetso tsa lihekhicmic le lisetleha tsa molomo, sodium cellulosese joalo ka bosholu le botsitso ba sethethefatsi nakong ea ts'ebeliso. Ntle le moo, e leng, bo-mme ba 'nang ba sebetsa hantle ka lebaka la biockatsi ho molemo le chefo,' me u se ba sebelisitsoe haholo lithethefatsing tse opa.
5. Lisebelisoa tsa Wall bakeng sa litokisetso tsa capsule
E-'Bala - e leng' mapollo a ka sebelisoa e le lisebelisoa tsa lebokoseng la litokisetso tsa caplule litokisetso tsa li-capsule tse thehiloeng ho limela. Lintho tsa moetlo oa setso ea khetla e boholo-holo ke keketseho ea limela le batho ba kulang mehloling ea ba lema bo ntse bo eketseha butle-butle mehloling ea limela e eketsehile butle butle. Ethe e bo-'mè ba selefora ea celdroypropypropy Mofuta oa katse o sa tsoakoang feela o na le matla le ho tsitsipana le botsitso le botsitso ho li-captians tsa gelatin.
6. Etsa kopo ka litokisetso tsa molomo le tsa holimo
E-ba-e-'e-ba-'mè ba sele cellulo ba boetse ba sebelisoa haholo ka litokisetso tsa molomo le tsa sehlooho. Ka lebaka la hodhesion ea eona e ntle le biocondomatic e ntle, e-bo-e-bo-'mōtoana ba celcoulo ba ka theha filimi e sirelletsang ka har'a motsu oa molomo kapa sebakeng sa letlalo, ba lelekisa nako ea ho etsa lithethefatsi. Mohlala, litafoleng tse hlahang ka molomo, lilithothong tsa menoang, li-cellular, e leng Chlyoulo Larses li ka bapala karolo ea lithethefatsi le ho ntlafatsa litlamorao tsa lithethefatsi.
7. Litsamaiso tsa li-cortems tsa ho tsamaisa lithethefatsi
E-'nete e se e ka sebelisoa hape bakeng sa kaho ea lihlahla tsa li-kou ea lithethefatsi le lits'ebetso tsa phepelo ea lithethefatsi. Ha li-amicapsules kapa li-nengoparcher, hangata e-ba-e-cell tsa khomphutha li sebelisoa e le lisebelisoa tsa lebota kapa li-bakuli ho fihlela li-apole tse tsitsitseng tsa ho sebelisa lithethefatsi. Mohlala, hydroxypropypropypropiyL methylcelulo le cebboxlcelll le celb E-ba se-e-se-'se-' nete ea se-cellulose e ke ke ea thibela lithethefatsi tse tsoang mathateng a tikoloho ea mabra.
Ba-'E-ba-bo-mme ba sebelisoa haholo indastering ea meriana, ba koahele masimo a fapaneng a ho bokella thepa e phahameng le ea bohlokoa ho phetoleho ea litšebeletso tsa lithethefatsi. Ka nts'etsopele e tsoelang pele ea theknoloji ea Phamema, e tla boela ea eketsoa, haholo-holo masimong a lits'ebetso tse ncha tsa lithethefatsi, o tla tsoela pele ho bapala karolo ea bohlokoa.
Poso: Hlakubele-17-2025